The COMET Congress, the scientific congress dedicated to cosmetic measurement and testing, is back in January 2025!
Our presentation will highlight our most recent development of 3D imaging techniques and 4D imaging analysis on vascular and lymphatic network in collaboration with PRISM Imaging Facility of Institut de Biologie Valrose and the application of such techniques in the work recently performed with Mibelle Biochemistry on VividEYE™.
This demonstrates the potential of our 3D vascularized adult tissue models derived from human subcutaneous fat tissue in supporting claims for dermo-cosmetic active ingredients, in particular related to face care, such as dark circles, under-eye bags and puffiness.
WHEN: January 22, 2025, 10:15 AM
WHERE: CY TECH, Cergy (France)
SESSION 1: SKIN MODELS: FROM EXPLANT TO ORGAN-ON-CHIP
TITLE: Combination of a novel donor-derived 3D vascularized adult organoid and 4D imaging analysis to support anti-dark circles and under-eye bags claims for dermo-cosmetic active ingredients
SPEAKER: Luigi Formicola, COO & Co-founder
ExAdEx technology allowed us to develop a unique 3D vascularized adult organoid model derived directly from human donor subcutaneous tissue. This model preserves the 3D vascular and lymphatic network ex vivo, offering a significant advancement over current 2D cell and 3D engineered vascular models and a more clinically relevant platform for testing dermo-cosmetic active ingredients.
Utilizing novel 4D computer-assisted volume reconstruction techniques, we have been able to create a toolset for quantitative evaluation of vascular and lymphatic networks. This method allows for measurement of parameters such as vessel surface, length, and network complexity.
The presentation will include application results from a study using Mibelle Biochemistry‘s VividEYE™, an apple mint extract, on ExAdEx vascularized 3D tissue models.
Combination of ExAdEx vascularized tissue models and novel 4D imaging analysis provides a powerful tool for supporting claims related to dark circles and under-eye bags treatments. It offers a unique visualization of active ingredients’ effects on 3D human vascular and lymphatic networks, advancing cosmetic science and validation of dermo-cosmetic products.
To explore how ExAdEx-Innov can transform your research and development processes in the dermo-cosmetic field, please check out our ExAdEx Platform capabilities and visit the conference website.
ExAdEx-Innov Drives Innovation in Cosmetic Industry: Contributing to the Development of VividEye™ from Mibelle Biochemistry We are thrilled to announce ExAdEx-Innov’s contribution to the research
Our Collaboration with Exsymol Monaco at the 34th Congress IFSCC Brazil 2024 We are excited to announce that our scientific research work performed in collaboration
Let’s explore innovation at the 10th edition of COSMETIC 360 tradeshow in Paris in October 2024! We are pleased to announce our participation in the
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KOL on adipose tissue biology.
Research Director (DR1 INSERM).
Team Leader of « Stem Cells and Differentiation » Lab at Institut de Biologie Valrose (Nice).
Label of Laboratoire d’Excellence by the French National Research Agency (Investissements pour le Futur, Labex Signalife program).
Co-inventor of 5 patents
Expert in clinical applications of adipose tissue.
Plastic Reconstructive and Aesthetic Surgeon in Nice.
Member of the Medical Council of Alpes Maritimes region.
Expert for the French National Regulatory Agency ANSM for medical devices.
Certified by French Health Autority HAS (2020-2024).
PhD thesis (2018) on fat tissue and adipose tissue stem cells grafting.
Expert in cell therapy and immunology.
Senior Lecturer (Maitre de conférences).
Responsible of the Cell and Gene Therapy Unity of Nice University Hospital (CHU de Nice).
Director of « Micoralis » research team at Université Côte d’Azur (Nice).
Founder and CEO of the biotech company Biointerférence (2003-2006).
Co-inventor of 5 patents.
Vincent is responsible of company strategy and technological innovation, thanks to his double skill set in science and deeptech startup development.
With a deep knowledge and vision about ExAdEx technology, Vincent has actively worked as a deeptech entrepreneur to push further the development of breakthrough innovative products around human adipose tissue, which lead him to create ExAdEx-Inov.
In addition to his entrepreneurial skills, Vincent has a strong background in biology (PhD in Cellular and Molecular Biology from Université Côte d’Azur) and training in clinical research management (CRA training at the Faculty of Medicine of La Timone, Marseille).
He is co-inventor of the 2 company’s patent families.
Main areas of expertise: DeepTech entrepreneur; Bioengineering of human adipose tissue.
Luigi is responsible of the management of company operations and business development strategy, thanks to his expertise in biotech startup development.
With a double competence and training in business and science (including an MBA from IAE Paris Sorbonne Business School and a PhD in Cytological Sciences from Rome University La Sapienza), Luigi has been managing business development and R&D projects in a preclinical CRO and a biotech startup company in previous years.
He has been supporting ExAdEx-Innov project and business development since his position as an Entrepreneur in Residence for CNRS Innovation Tech Transfer Office in 2021.
Main areas of expertise: Biotech Startup Business Development; Project management
