A comprehensive R&D platform of ex vivo human adipose tissue
Adding value to adipose tissue R&D through original tools and approach
We provide the cosmetic, nutraceutic and pharmaceutical industry with a unique technological platform to unravel the complexity of human adipose tissue biology and upgrafe efficacy and safety testing.
Our physio-pathological 3D ex vivo models of human white and beige adipose tissue integrate the complexity of the native adipose tissue biology and provide an original approach for the evaluation and claim substantiation of cosmetic and nutraceutical ingredients as well as drug candidates, based on innovative and highly differentiating criteria.
ExAdEx R&D platform allow to characterize the biological effects of the products of interest on a fully competent tissue structure resembling the native context and evaluate their efficacy on pathological conditions involved in skin ageing and skin health, weight management, metabolic disorders, lipodystrophies, etc.
Leveraging native adipose tissue properties
First-in-class Micro-Physiological Models of Human Adipose Tissue
Why reproducing and mimicking human fat tissue by assembling different components in vitro or using poorly translational animal models when you can leverage what already exists in nature: the native human fat tissue?
Current R&D models for adipose tissue are poorly relevant of native physiology and pathological states, thus failing to predict target engagement and in vivo human efficacy and safety of fat-targeting drugs or compounds.
Starting from surgical waste subcutaneous fat material, ExAdEx technology allows to generate the first physiological, fully competent and clinically relevant human adipose tissue R&D models.
Our main innovation relies on the ability of adipose stem cells to proliferate in response to mechanical stimuli and the use of the native extracellular matrix as a bioactive support.
ExAdEx physiological adipose tissue models display the 3D structural and functional characteristics of native tissue:
- long-term viability in culture (up to 2 months)
- full extracellular matrix structure
- lipid droplet sizes comparable to endogenous tissue
- cellular heterogeneity (progenitors, mature adipocytes, immune cells)
- vascular and lymphatic network
- endocrine function
- able to mimic physiological responses, such as beiging, lipolysis, lipogenesis
- able to mimic pathological responses, such as inflammation and fibrosis as found in obesity and metabolic disorders.
ExAdEx technology was developed in French research excellence labs (CNRS/INSERM).
