RESEARCH PLATFORM
FOR DERMO-COSMETIC TESTING

UNIQUE REAL HUMAN TISSUE MODELS

Our platform uses real ex vivo tissue models derived from human donor fat to support dermo-cosmetic, nutraceutical and aesthetic medicine research with innovative claims validation testing.
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Real 3D Ex vivo Tissue models
for first-in-human data generation

3D EX VIVO TISSUE MODELS
3D EX VIVO TISSUE MODELS
MULTI-PARAMETRIC ANALYSIS
MULTI-PARAMETRIC ANALYSIS
MARKETING SUPPORT
MARKETING SUPPORT
DARK CIRCLES,
PUFFY EYES, UNDER-EYE SAGGING
ExAdEx vascularized 3D adult organoid models obtained from freshly isolated subcutaneous adipose tissue allow to support claims related to vasoconstriction, vasodilation, stimulation of lymphatic network and drainage
Vascular/Lymphatic
ANTI-AGING, SKIN HEALTH,
TISSUE REGENERATION
ExAdEx donor-derived 3D inflammatory and fibrotic tissue models mimic complex skin interactions, allowing for claim substantiation of tissue remodeling, anti-stress, regenerative and anti-aging products
Physio-Pathological
FAT BURNING,
METABOLIC ACTIVITY
ExAdEx 3D real fat tissue models are the only clinically relevant ex vivo models with physiological fat burning and browning capacity, supporting claims targeting weight management, cellulite and metabolic well-being
Fat burning
ExAdEx physio-pathological 3D vascularized and functional models are a relevant alternative to animal testing and provide an original approach for the repositioning of dermo-cosmetics, nutraceutical products and aesthetic regenerative medicine products through evaluation of multiple claims at once, all in single multi-parametric studies.
ExAdEx 3D tissue models are directly derived from human donor subcutaneous adipose tissue, allowing for first-in-human data generation. Thanks to the ExAdEx patented breakthrough technology, our 3D models are alive for up to 8 weeks in tailored unique culture conditions, can reproduce inflammatory and fibrotic stress and preserve the donor's extracellular matrix, vascular and lymphatic networks.
Our cutting-edge ExAdEx platform offers unparalleled insights into tissue-level effects using state-of-the-art 3D imaging and analysis techniques, combining innovative technologies to mimic in vivo conditions and uncover critical biological data. ExAdEx technological platform has a strong and deep connection with French academic research of excellence (CNRS, INSERM, Université Côte d’Azur/IdEx) with decades of expertise in generation of relevant tissue models.
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The real proxy for human adipose tissue

  • The first micro-physiological and fully competent 3D adult fat tissue models
  • Suitable for dermo-cosmetic, nutraceutical and injectable products testing
  • Directly derived from donors for maximal human data relevance
  • Preserving native structure, microenvironment and biological responses thanks to a patented innovation
  • Generating first-in-human data in the lab
  • Long term viable in 3D culture conditions for assessment of structural long term effects

OUR COLLABORATORS

"Our collaboration with ExAdEx-Innov went beyond our expectations. A team of agile, proactive and available experts who successfully completed our project to develop a dermocosmetic ingredient using their innovative model"
EXSYMOL
EXSYMOLDesigner of active ingredients
"Our collaboration with ExAdEx-Innov allowed us to explore and quantify the structure of emulsified fat used in regenerative medicine and previously unexplored"
CENTRE DE RECHERCHE EN CARDIOVASCULAIRE ET NUTRITION
CENTRE DE RECHERCHE EN CARDIOVASCULAIRE ET NUTRITIONMedical Institute of Research
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We are happy to answer all your questions, discuss your needs and provide you with tailored solutions.
Please contact us and we will answer as soon as possible.
EXADEX-INNOV
Bioincubateur
Institut de Biologie Valrose
28 Avenue de Valombrose
06100 Nice (FRANCE)

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KOL on adipose tissue biology.

Research Director (DR1 INSERM).
Team Leader of « Stem Cells and Differentiation » Lab at Institut de Biologie Valrose (Nice). 

Label of Laboratoire d’Excellence by the French National Research Agency (Investissements pour le Futur, Labex Signalife program). 

Co-inventor of 5 patents

Expert in clinical applications of adipose tissue.

Plastic Reconstructive and Aesthetic Surgeon in Nice.

Member of the Medical Council of Alpes Maritimes region.

Expert for the French National Regulatory Agency ANSM for medical devices.

Certified by French Health Autority HAS (2020-2024).

PhD thesis (2018) on fat tissue and adipose tissue stem cells grafting.

Expert in cell therapy and immunology. 

Senior Lecturer (Maitre de conférences).

Responsible of the Cell and Gene Therapy Unity of Nice University Hospital (CHU de Nice).

Director of « Micoralis » research team at Université Côte d’Azur (Nice).

Founder and CEO of the biotech company Biointerférence (2003-2006).

Co-inventor of 5 patents.

Vincent is responsible of company strategy and technological innovation, thanks to his double skill set in science and deeptech startup development.

With a deep knowledge and vision about ExAdEx technology, Vincent has actively worked as a deeptech entrepreneur to push further the development of breakthrough innovative products around human adipose tissue, which lead him to create ExAdEx-Inov. 

In addition to his entrepreneurial skills, Vincent has a strong background in biology (PhD in Cellular and Molecular Biology from Université Côte d’Azur) and training in clinical research management (CRA training at the Faculty of Medicine of La Timone, Marseille). 

He is co-inventor of the 2 company’s patent families. 

Main areas of expertise: DeepTech entrepreneur; Bioengineering of human adipose tissue. 

Luigi is responsible of the management of company operations and business development strategy, thanks to his expertise in biotech startup development.

With a double competence and training in business and science (including an MBA from IAE Paris Sorbonne Business School and a PhD in Cytological Sciences from Rome University La Sapienza), Luigi has been managing business development and R&D projects in a preclinical CRO and a biotech startup company in previous years. 

He has been supporting ExAdEx-Innov project and business development since his position as an Entrepreneur in Residence for CNRS Innovation Tech Transfer Office in 2021.

Main areas of expertise: Biotech Startup Business Development; Project management