EXADEX Platform

Real Human Adipose Tissue Ex vivo models for Dermo-Cosmetic Testing and Drug Development

Unique 3D models of real human adipose tissue preserving the structure, microenvironment and biological responses thanks to a patented innovation

The first micro-physiological and fully competent 3D adult organoids of human adipose tissue
Vascularized and functional fat tissue ex vivo
Generating first-in-human data 
Long term viable in 3D culture conditions
Native fat units directly derived from donors, with no exogenous material
Suitable for dermo-cosmetic, nutraceutical and drug development testing

KNOW-HOW AND INNOVATION

VASCULAR AND LYMPHATIC
NETWORK
Healthy vascular and lymphatic networks are crucial for a healthy skin and fat tissue physiology. Alterations in these networks can be found in physiological and pathological conditions, such as overweight, obesity and cellulite.
3D ExAdEx human adipose tissue models retain a complex and structured 3D vascular and lymphatic network, allowing for claim substantiation and efficacy testing of pro-vascular and pro-lymphatic products in a human relevant environment ex vivo.
In-house advanced 3D/4D imaging know-how brings impactful and original visual outcome of cosmetics, nutraceutical ingredients and drugs, deep down at the core of 3D ExAdEx adipose tissues.
Claim a network effect
INFLAMMATORY STRESS
AND FIBROSIS
Acute and chronic inflammatory stress of fat tissue in vivo induce changes in the tissue matrix and fat tissue function and metabolism. Fibrosis of fat tissue changes skin appearance and health, leading to cellulite. Fibro-inflammation is associated to obesity and chronic metabolic diseases .
3D ExAdEx human adipose tissue models are unique as they retain the real, natural tissue matrix of fat tissue ex vivo, allowing for claim substantiation and efficacy testing of extracellular matrix remodeling, anti-inflammatory stress, anti-cellulite and anti-obesity products.
Combination of molecular, functional and 3D/4D imaging techniques provide innovative first-in-human data for new claims and mechanisms of action in a pathological contexte.
Pathological context
FAT BURNING
AND METABOLIC ACTIVITY
Fat tissue is the main energy reservoir of the human body, but also a complex organ with endocrine function and thermogenesis capacity (also known as fat burning or beiging), which plays a key role in regulation of metabolism, weight management and prevention of obesity.
3D ExAdEx human adipose tissue models are the only ex vivo native tissue models that show a natural and physiological fat burning capacity and clinically relevant beiging differentiation in response to active ingredients and pharmacological compounds, allowing for efficacy testing of products targeting weight management and obesity.
Thermogenesis, fat burning and fat melting, lipolysis and beiging differentiation can be claimed and tested in a clinically relevant ex vivo context on real human fat derived from donors, at the cellular, molecular and functional level, on the only human beige tissue model available on the market.
Beiging induction
Our physio-pathological 3D vascularized and functional models of human adipose tissue are an alternative to animal testing and provide an original approach for the repositioning of cosmetics and nutraceutical products through evaluation of new claims or for the assessment of efficacy of cosmetic and nutraceutical ingredients and drugs, all in a single multi-parametric study.
ExAdEx 3D adipose tissue models are directly derived from human donors, allowing for first-in-human data generation in vitro. Thanks to ExAdEx patented technology, our 3D models are kept alive for more than 60 days in tailored culture conditions, reproduce inflammatory and fibrotic stress conditions, show alteration in extracellular matrix, vascular and lymphatic networks and can be visualized by advanced 3D imaging techniques for marketing and scientific purposes.
ExAdEx technological platform has originated in renowned French academic laboratories (CNRS, INSERM, Université Côte d’Azur supported by IdEx excellence and innovation program). We aim to be a comprehensive partner research organization, bringing deep expertise and know-how in adipose tissue biology and in novel differentiating mechanisms of actions, as well as providing added value to cosmetic, nutraceutical and pharmaceutical research and testing, thanks to a team of high-ranked scientific authors and key opinion leaders in the field.
Click here lo learn more about our testing tools

Get in touch

We are happy to answer all your questions, discuss your needs and provide you with tailored solutions in the human adipose tissue field.
Please contact us and we will answer as soon as possible.
EXADEX-INNOV
Bioincubateur
Institut de Biologie Valrose
27 Rue Professeur Delvalle
06000 NICE – FRANCE

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KOL on adipose tissue biology.

Research Director (DR1 INSERM).
Team Leader of « Stem Cells and Differentiation » Lab at Institut de Biologie Valrose (Nice). 

Label of Laboratoire d’Excellence by the French National Research Agency (Investissements pour le Futur, Labex Signalife program). 

Co-inventor of 5 patents

Expert in clinical applications of adipose tissue.

Plastic Reconstructive and Aesthetic Surgeon in Nice.

Member of the Medical Council of Alpes Maritimes region.

Expert for the French National Regulatory Agency ANSM for medical devices.

Certified by French Health Autority HAS (2020-2024).

PhD thesis (2018) on fat tissue and adipose tissue stem cells grafting.

Expert in cell therapy and immunology. 

Senior Lecturer (Maitre de conférences).

Responsible of the Cell and Gene Therapy Unity of Nice University Hospital (CHU de Nice).

Director of « Micoralis » research team at Université Côte d’Azur (Nice).

Founder and CEO of the biotech company Biointerférence (2003-2006).

Co-inventor of 5 patents.

Vincent is responsible of company strategy and technological innovation, thanks to his double skill set in science and deeptech startup development.

With a deep knowledge and vision about ExAdEx technology, Vincent has actively worked as a deeptech entrepreneur to push further the development of breakthrough innovative products around human adipose tissue, which lead him to create ExAdEx-Inov. 

In addition to his entrepreneurial skills, Vincent has a strong background in biology (PhD in Cellular and Molecular Biology from Université Côte d’Azur) and training in clinical research management (CRA training at the Faculty of Medicine of La Timone, Marseille). 

He is co-inventor of the 2 company’s patent families. 

Main areas of expertise: DeepTech entrepreneur; Bioengineering of human adipose tissue. 

Luigi is responsible of the management of company operations and business development strategy, thanks to his expertise in biotech startup development.

With a double competence and training in business and science (including an MBA from IAE Paris Sorbonne Business School and a PhD in Cytological Sciences from Rome University La Sapienza), Luigi has been managing business development and R&D projects in a preclinical CRO and a biotech startup company in previous years. 

He has been supporting ExAdEx-Innov project and business development since his position as an Entrepreneur in Residence for CNRS Innovation Tech Transfer Office in 2021.

Main areas of expertise: Biotech Startup Business Development; Project management