Obesity is associated with chronic metabolic diseases, such as MASH, steatosis, type-2 diabetes and cardiovascular diseases. Despite the emergence of novel effective treatments in recent years, millions of people with obesity remain with no tailored therapeutic solution, in particular patients who are poorly responding to anti-obesity drugs.

In obesity, the balance between white adipose tissue (the ‘bad’ fat) and brown adipose tissue (the ‘good’ fat) is altered, with white adipose tissue accumulating and becoming dysfunctional, while brown adipose tissue disappears or is impaired. Brown adipose tissue is known for its energy expenditure capabilities and to regulate metabolism by secreting specific factors preventing chronic metabolic diseases.

Stimulating or restoring these natural beneficial properties of adipose tissue through 'browning' of white adipose tissue can have a profound impact on obesity management and pave the way for a comprehensive therapeutic approach for obesity.